Substance P Increases the Polymorphism of the Synaptic Vesicles

What is it about?

not only as an excitatory transmitter of the first afferent synapse of pain pathways but as a valuable neuromodulator in the primary cortical areas of sensosensorial integration. In the human acoustic cortex, substance P has been found in the presynaptic terminals as well as in the cell bodies of numerous polyhedral, triangular and bipolar neurons. Using histochemical techniques, we found recently that substance P is first accumulated in the neuronal elements of the human acoustic cortex in 18-gestational-week (GW) fetuses. Most of substance Pis distributed in the neurons of the 3rd and 4th cortical layers, mainly in the cell bodies, the initial part of the axons and the axonic terminals. In 24-GW fetuses, substance P is found in the 2nd cortical area inside the cell body of the granular and bipolar neurons. In 28-GW fetuses, substance P is found in the pre- and postsynaptic terminals. We would suggest that substance P is accumulated increasingly as a function of the neuronal maturity of the primary acoustic cortical area, serving mainly as a neuromodulator.

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Why is it important?

The presence of substance P in a substantial number of cortical neurons constitutes firm evidence that it might play an important role in the primary sensosensorial memory and in a further analysis of the perception, since the primary reception of the external stimuli via the specific sensorial organs is a process of continuous neuronal interaction, registration, analysis, codification and critical revision, which take place mainly at the cortical level

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