What is it about?
Embryogenesis becomes dependent on de novo synthesized RNAs of embryonic genome.Autoradiographic study on in vitro produced bovine embryos cultured to the late 8-cell stage with or without (control group) α-amanitin. Inhibition of RNA polymerase II (RNA pol II) already in the early phases of embryonic genome activation has detrimental effect on nucleolar formation and embryo survival, what was shown for the first time.
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Why is it important?
Inhibition of RNA polymerase II (RNA pol II) already in the early phases of embryonic genome activation has detrimental effect on nucleolar formation and embryo survival, what was shown for the first time
Perspectives
Toxicity studies to detect detrimental effect of RNA pol II inhibition
Professor jan Lehotsky
Comenius University in Bratislava, Jessenius Medical Faculty in Martin
Read the Original
This page is a summary of: The role of RNA-polymerase II transcription in embryonic nucleologenesis by bovine embryos, Biologia, January 2010, De Gruyter,
DOI: 10.2478/s11756-010-0046-2.
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