What is it about?

Methotrexate is widely used in Dermatology for psoriasis and many other conditions, including bullous disorders, autoimmune connective tissue diseases, pityriasis rubra pilaris, sarcoidosis, and miscellaneous other dermatoses. We report 2 cases of MTX-induced reduced libido and erectile dysfunction.

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Why is it important?

We report two cases of Methotrexate induced sexual dysfunction in order to raise awareness of this adverse effect.


To the best of our knowledge, there have been only 2 cases in the literature of this rare side-effect in patients with psoriasis treated with MTX. We assume, therefore, that MTX-associated sexual dysfunction may be under-reported. Taking into consideration that patients with psoriasis have a higher risk of sexual dysfunction irrespective of treatment, compared with the general population. It is important to make a careful assessment of sexual function both at the initial and follow-up visits

Dr Grigorios Theodosiou
Region Skane

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This page is a summary of: Methotrexate-associated Sexual Dysfunction: Two Case Reports, Acta Dermato Venereologica, January 2017, Acta Dermato-Venereologica,
DOI: 10.2340/00015555-2714.
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