What is it about?
We studied 810 individuals with new onset type 1 diabetes and found that those who had the type 2 diabetes version (allele) of a gene, compared with those who did not, were more likely to have fewer of the islet autoantibodies that are typical in type 1 diabetes but more indicators of insulin resistance, which is typical of type 2 diabetes.
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Why is it important?
Our findings suggest that some individuals may have a combination of type 1 diabetes (that is, their immune system attacked the cells that make insulin) and type 2 diabetes (that is, their body does not use insulin efficiently). This has implications for how we predict, prevent, diagnose and treat their diabetes since they may need strategies that address both types of defect.
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This page is a summary of: TCF7L2
Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes, Diabetes Care, October 2017, American Diabetes Association, DOI: 10.2337/dc17-0961.
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