What is it about?
This work reveals a role for vitamin D receptor (VDR) in β-cell physiology and in protection from diabetes. We have shown that the expression of vitamin D receptor is downregulated in β-cells during the development of both type 1 and type 2 diabetes. Contrasting, overexpression of the receptor in β-cells protects against diabetes development, at least in mice.
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Why is it important?
Our findings show that VDR expression sustained levels in β-cells in diabetes context can be clue to protected them from the cell-damage. Also, the islet VDR downregulation during the diabetes development might help explain the mixed results that show vitamin D supplementation may or may not be beneficial in terms of glucose metabolism in diabetes.
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This page is a summary of: Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice, Diabetes, February 2020, American Diabetes Association, DOI: 10.2337/db19-0757.
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