What is it about?

Reprogramming of cancer cells is an innovative model for study of cancer stem cells. Here we report our successful reprogramming of the liver cancer cells into iPSC-like cells, which yielded high tumor-formation in immunocompromised mice.

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Why is it important?

The aggressive phenotype of this cancer stem cell-like clone is resulted from upregulation of c-JUN oncogene, which was activated by OCT4 in a positive feedback manner.

Perspectives

This manuscript help to understand the target genes which generate the cancer stem cell like cells for liver cancer.

Kazunari K. Yokoyama
Kaohsiung Medical University

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This page is a summary of: Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer, Stem Cells, July 2016, Wiley, DOI: 10.1002/stem.2447.
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