What is it about?
Cellular responses to mechanical injury include producing matrix-remodeling enzymes, inflammatory cytokines, and active cell death (apoptosis). Together, these responses can weaken the cartilage and promote arthritis. We identified Cdk9 activity as an important factor connecting mechanical impact to these cellular activities. Preventing Cdk9 activity protected cartilage after mechanical impact.
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Why is it important?
Certain cellular activities that occur after a joint injury can actually harm the joint in the long-term and lead to arthritis. A better understanding of these cellular activities can help us reduce the risk of arthritis.
Perspectives
This is part of a series of manuscripts looking at how Cdk9 is involved in post-traumatic osteoarthritis, with each set of experiments performed in a more complex model system. In the first manuscript, we used a cell-culture approach to identify mechanisms. In this current manuscript, we use cartilage explants as a model system. In upcoming manuscripts, we will use animal models of joint injury.
Professor Dominik R Haudenschild
Houston Methodist
Read the Original
This page is a summary of: Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants, October 2015, ECM Research Journal,
DOI: 10.22203/ecm.v030a14.
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