What is it about?
This review discusses latest advances in genome localization of genome-wide association studies variants, whole genome/whole exome data analysis, protein-protein interactions networks databases, and more recent Encyclopedia of DNA Elements (ENCODE) data on regulatory networks including transcription factors-binding sites and gene-gene interactions
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Why is it important?
In addition challenges for a comprehensive analysis of intracellular signaling pathways network is described. Such analysis, despite genome-scale scarce data and lack of sophisticated methods to predict dynamics of a global hierarchy or 'cloud" of biological networks, appears essential for the discovery of new therapeutic network targets, which could potentially help in the treatment minimizing at the same time major adverse effects.
Perspectives
This review describes potential and challenges of modern approaches for applying next-generation sequencing and patient's personal whole genome analysis for personalized treatment using available drugs and the discovery of next-generation drugs based on genome science and network biology advances.
Dr Demosthenes E. Ziogas
Peripheral General Hospital of Ioannina - Xatzikosta
Read the Original
This page is a summary of: Novel Wnt signaling and other pathway inhibitors in the colorectal cancer genomic landscape era, Future Oncology, November 2012, Future Medicine,
DOI: 10.2217/fon.12.140.
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