Intensity of Chemotherapy For The Initial Management of Newly Diagnosed Acute Myeloid Leukemia In Older Patients

What is it about?

Treatment of AML in older adults is difficult as these patients are typically more frail and may not tolerate standard of care high-intensity induction chemotherapy. Less intense therapies, such as hypomethylating agents are of interest as they may be better tolerated. This retrospective trial demonstrates that decitabine, a hypomethylating agent, is no different in overall survival when compared to high-intensity chemotherapy in older adults.

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