Action of Thioglycosides of 1,2,4-Triazoles and Imidazoles on the Oxidative Stress and Glycosidases in Mice with Molecular Docking

Mahmoud Balbaa, Doaa Awad, Ahmad Abd Elaal, Shimaa Mahsoub, Mayssaa Moharram, Omayma Sadek, Nadjet Rezki, Mohamed Reda Aouad, Mohamed El-Taher Ibrahim Badawy, El Sayed Helmy El Ashry
  • Letters in Drug Design & Discovery, May 2019, Bentham Science Publishers
  • DOI: 10.2174/1573413715666181212150955

Action of Thioglycosides on the Oxidative Stress and Glycosidases.

Photo by Michael Lee on Unsplash

Photo by Michael Lee on Unsplash

What is it about?

In vitro and in vivo effects of different types of thioglycosides were thoroughly investigated. The obtained results were confirmed by studying the mode of binding by docking studies.

Why is it important?

Our finding show that the inhibition of α-glucosidase is accompanied by an oxidative stress action.

Perspectives

Mahmoud Balbaa

Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research.

Read Publication

http://dx.doi.org/10.2174/1573413715666181212150955

The following have contributed to this page: Dr Doaa Osman Awad, Nadjet REZKI, El Sayed H. El Ashry, Professor Mohamed E. I. Badawy, Mahmoud Balbaa, Ahmed AbdElaal, Omayma Sadek, and Shimaa Mahsoub