What is it about?
Advantages of chronotherapy include a greater effectiveness of treatment, reduced dose of required drugs, and minimized adverse effects. This review presents data on the presence of circadian rhythms of spontaneous and induced cytokine production, as well as the expression of cytokine receptors in the healthy body and in a number of diseases. The article presents the results of chronotherapeutic modes of administering IL-2, interferons, G-CSF, and GM-CSF in treatment of various types of cancer as well as in experimental models of immune suppression and inflammation, which lead to a greater effectiveness of therapy, the possibility of reducing or increasing the dosage, and reduced drug toxicity. Further research in this field will contribute to the effectiveness and safety of cytokine therapy. - See more at: http://www.eurekaselect.com/134813/article#sthash.W6rPkok6.dpuf
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Why is it important?
Numerous studies have found a positive effect in using cytokines to treat a variety of diseases, yet the clinical use of cytokines is limited by their toxicity. Research in the field of chronotherapy may contribute to the solution of this problem. Advantages of chronotherapy include a greater effectiveness of treatment, reduced dose of required drugs, and minimized adverse effects.See more at: http://www.eurekaselect.com/134813/article#sthash.W6rPkok6.dpuf
Perspectives
In recent times, a number of diseases involving immune system dysfunction have appeared. This increases the importance of research aimed at finding and developing optimized methods for immune system correction. The time of administration immunoactive drugs significantly affects their effect. In the best case, the drug is ineffective when used in certain phases of the diurnal cycle, at worst - the effects of various daily modes are inverted. Thus, the choice of an appropriate daily regimen of the cytokine can increase the effectiveness of therapy, reduce its toxicity and allow decrease the dose of the drug. See more at: http://www.eurekaselect.com/134813/article#sthash.W6rPkok6.dpuf
Dr Anna V Shurlygina
Scientific Research Institute of Physiology and Basic Medicine under the Siberian Branch of the Russian Academy of Medical Sciences
Read the Original
This page is a summary of: Circadian Rhythm in Cytokines Administration, Mini-Reviews in Medicinal Chemistry, October 2015, Bentham Science Publishers,
DOI: 10.2174/1389557515666150909143515.
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