What is it about?
Many research goes into developing cancer drugs daily, prostate cancer especially. In recent investigations, CREB-binding protein has been identified as a potential target for novel drugs in castration resistant prostate cancer. In one of these investigations, we came across a novel drug testified under in vivo and in vitro studies to possess therapeutic anti-cancer properties . Hence, we carried out an in silico experiment to confirm this result as well as identify the culprit behind this miracle.
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Why is it important?
The use of computational tools in this research showed the interaction dynamics between the target and the novel drug. With this knowledge, the modality of pharmacodynamics and pharmacokinetics is best understood. Also, further attesting the novel drug to processed to clinical trials.
Perspectives
This research strengthened my faith in science and technology. To be part of a community making a difference has always been my dream. Hence, despite the challenges associated with research, working on this project was fulfilling and satisfying.
oluwayimika akinsiku
University of KwaZulu-Natal
Read the Original
This page is a summary of: Exploring the Role of Asp1116 in Selective Drug Targeting of CREBcAMP- Responsive Element-binding Protein Implicated in Prostate Cancer, Combinatorial Chemistry & High Throughput Screening, May 2020, Bentham Science Publishers,
DOI: 10.2174/1386207323666200219122057.
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