What is it about?
DNA triple helices are non-cannonical DNA structures that can be use for regulation of gene expression. We review the studies of these structures especially in the area of design of novel nucleosides that enhance the thermodynamic stability of these structures in order to generate modified oligonucleotides with enhanced binding properties to their DNA or RNA targets
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Why is it important?
Modified triplex-forming oligonucleotides have interesting properties in regulation of gene expression, mutation repair and as capture probes for diagnostics. Increasing thermodynamic stability on triplex formation may provide novel tools with higher efficacy as drugs or as capture probes in DNA biosensing.
Perspectives
The article was an excellent opportunity to collaborate between three spanish groups especialized in nucleic acids chemistry. It gave us an excellent perspective on the field of oligonucleotide design that was the basis for future collaborations.
Ramon Eritja
CSIC
Read the Original
This page is a summary of: Nucleic Acid Triple Helices: Stability Effects of Nucleobase Modifications, Current Organic Chemistry, December 2002, Bentham Science Publishers, DOI: 10.2174/1385272023373482.
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