Nucleic Acid Triple Helices: Stability Effects of Nucleobase Modifications

  • Jordi Robles, Anna Grandas, Enrique Pedroso, F. Luque, Ramon Eritja, Modesto Orozco
  • Current Organic Chemistry, December 2002, Bentham Science Publishers
  • DOI: 10.2174/1385272023373482

DNA triple helices and biomedicine

What is it about?

DNA triple helices are non-cannonical DNA structures that can be use for regulation of gene expression. We review the studies of these structures especially in the area of design of novel nucleosides that enhance the thermodynamic stability of these structures in order to generate modified oligonucleotides with enhanced binding properties to their DNA or RNA targets

Why is it important?

Modified triplex-forming oligonucleotides have interesting properties in regulation of gene expression, mutation repair and as capture probes for diagnostics. Increasing thermodynamic stability on triplex formation may provide novel tools with higher efficacy as drugs or as capture probes in DNA biosensing.


Ramon Eritja

The article was an excellent opportunity to collaborate between three spanish groups especialized in nucleic acids chemistry. It gave us an excellent perspective on the field of oligonucleotide design that was the basis for future collaborations.

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