What is it about?
This review examines clinical evidence on advanced oxidation protein products (AOPPs) as biomarkers of oxidative stress. AOPPs are mainly generated by chlorinated oxidants produced by myeloperoxidase activity and are found to accumulate across multiple inflammatory and immune‑related conditions.
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Why is it important?
Oxidative stress contributes to the development and maintenance of inflammation and abnormal immune responses. Understanding whether AOPPs reflect oxidative injury may help in confirming inflammatory or immune‑mediated conditions and in monitoring therapeutic strategies across heterogeneous diseases.
Perspectives
Reported pathologies show substantial heterogeneity, indicating that AOPPs are not merely markers of neutrophil activation nor consistent disease determinants. While useful for in vitro diagnostic support, AOPP levels may not clearly mirror causal involvement in disease pathogenesis or progression, highlighting the need for careful contextual interpretation.
Prof. Antonio Speciale
University of Messina
Read the Original
This page is a summary of: Circulating Advanced Oxidation Protein Products as Oxidative Stress Biomarkers and Progression Mediators in Pathological Conditions Related to Inflammation and Immune Dysregulation, Current Medicinal Chemistry, November 2016, Bentham Science Publishers,
DOI: 10.2174/0929867323666160902154748.
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