What is it about?

In Algerian traditional medicine, Centaurea species are well known in traditherapy. Centaurea africana has been used in folk medicine for the treatment of several inflammatory disorders. The objectives of this research were to evaluate total phenolic content (TPC), total flavonoid content (TFC), as well as the antioxidant, anti-inflammatory and anti-proliferative potential of both n-Butanol (BECA) and ethyl acetate (EAECA) extracts of Centaurea africana.

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Why is it important?

The obtained results indicated that EAECA exhibited a high antioxidant activity, while BECA has significant anti-inflammatory activity. Both extracts showed cytotoxic effects against cancer cell lines at certain concentrations in a cell-specific manner.

Perspectives

Further studies can be performed for the isolation and identification of the phenolic compounds of the fractions. In vivo studies can also be applied to understand the mechanisms of antioxidant and anti-inflammation properties exerted by Centaurea africana.

Sabrina Hadjira
University of Mentouri Brothers-, Constantine, Algeria.

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This page is a summary of: Antioxidant, Anti-Inflammatory and Cytotoxicity Properties of Centaurea africanaLamk var. [Bonnet] M, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, June 2020, Bentham Science Publishers, DOI: 10.2174/1871523019666200609140532.
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