What is it about?
The nonsteroidal compounds 2-amino-3-iodonaphthalene-1,4-dione and 2-(iodoamino)-3-methylnaphthalene-1,4-dione have been shown to prevent the formation of 3α- and 3β-androstanediols, thereby increasing dihydrotestosterone concentrations in cells. Importantly, these compounds do not bind to the androgen receptor, consistent with pharmacological experiments showing they do not reduce prostate and seminal vesicle weight in testosterone-treated castrated hamsters. These compounds may have promising therapeutic potential for nasal administration in older patients, as they could help elevate neuronal dihydrotestosterone levels.
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Why is it important?
Introducing innovative non-steroidal compounds designed to effectively elevate dihydrotestosterone levels within cells.
Perspectives
Compounds 2-amino-3-iodonaphthalene-1,4-dione and 2-(iodoamino)-3-methylnaphthalene-1,4-dione may have promising therapeutic potential for nasal administration in older patients, as they could help elevate neuronal dihydrotestosterone levels.
Dr Marisa Cabeza
Universidad Autónoma Metropolitana-Xochimilco
Read the Original
This page is a summary of: New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway, Current Enzyme Inhibition, March 2022, Bentham Science Publishers,
DOI: 10.2174/1573408018666220106151712.
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