What is it about?
Cancer involves multiple proteins to be over-expressed with its prognosis. Phytochemicals are small molecules that can inhibit this overexpression. Considering major lung cancer targets, this study performs screening to highlight the hit molecules that can potentially act as multitargeted inhibitors.
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Why is it important?
Ling cancer is a major cause of deaths world-wide. Restricting the growth of cancer in early stages can add some extra years. Potent bioactive compounds with significant anti-cancer activity can provide a less-expensive alternative in the cancer treatment. Screening the phytochemicals as multi-targeted inhibitors of cancer receptors will aid to increase the success rate in hit-to-lead optimization of anti-cancer agents.
Perspectives
Despite the advancements in cancer treatments, the quest to establish anti-cancer agents signifies the need of less-expensive alternatives that can inhibit the cancer prognosis. With our modern day lifestyles, a majority of population encounter frequent exposure to carcinogenic stimulus. Daily intake of selected phytochemicals seemed to aid in curbing cancers. This study addresses lung cancer and its targets, thereby highlighting the hit molecules present in the bark of Terminalia arjuna.
Tathagata Adhikary
Jadavpur University
Read the Original
This page is a summary of: In-silico Approach to Investigate the Phytochemicals of Terminalia arjuna
as Multitarget Inhibitors of Proteins Involved with Lung Cancer, Letters in Drug Design & Discovery, February 2024, Bentham Science Publishers,
DOI: 10.2174/1570180819666220913150304.
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