What is it about?

A list of drugs that can induce takotsubo cardiomyopathy (TCM) was published in 2011 and 2016. Similar to the 2011 and 2016 reviews, from April 2015 to May 2022 case reports of druginduced TCM were identified by a comprehensive search in Medline/PubMed database.

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Why is it important?

A list of 18 drugs as possible triggers of TCM were identified in the 2022 update. Of them, 3 (16.7%) have been previously identified, and 15 (83.3%) are different from the previous reports. Thus, the list of drugs as possible triggers of TCM updated in 2022 includes 72 drugs.


A list of 72 drugs associated to trigger Takotsubo Cardiomyopathy is available (mainly drugs that generate sympathetic overstimulation). Clinicians should be to consider and to identify the possible development of drug-induced Takotsubo Cardiomyopathy, mainly patients in which no clear emotional or stress trigger could be recognize.

Universidad de Antioquia

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This page is a summary of: Drugs as Possible Triggers of Takotsubo Cardiomyopathy- Update 2022: Systematic Review, Current Vascular Pharmacology, September 2023, Bentham Science Publishers,
DOI: 10.2174/1570161121666230517121037.
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