What is it about?

The article "High-Intensity Interval Training Prevents Cognitive Impairment and Increases Muscle FNDC5 and PPARGC1A Gene Expression in an Alzheimer's Disease Rat Model" describes a study conducted on rats with Alzheimer's disease. The study found that high-intensity interval training (HIIT) helped prevent cognitive impairment and increased the expression of muscle genes FNDC5 and PPARGC1A, which are important for muscle function and brain health. This suggests that HIIT may have potential as a therapeutic intervention for Alzheimer's disease.

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Why is it important?

Studying the relationship between FNDC5 and Alzheimer's disease is important because it can help us better understand the underlying mechanisms of the disease and potentially lead to new therapeutic interventions. FNDC5 is a gene that codes for a protein called irisin, which is produced in muscles during exercise and has been shown to have beneficial effects on the brain, including promoting neurogenesis and improving cognitive function. Alzheimer's disease is characterized by cognitive decline and the accumulation of abnormal proteins in the brain, which ultimately lead to neuronal death.


We intend to present in an upcoming article the protein response of the FNDC5 and APP proteins in the hippocampus of animals induced with Alzheimer's disease by beta-amyloid, suggesting that the post-exercise increase of Irisin may come from the cleavage of the brain protein, not necessarily only from the muscle protein.

Welton weltongodinho
Universidade Estadual do Ceara

Read the Original

This page is a summary of: High-Intense Interval Training Prevents Cognitive Impairment and Increases the Expression of Muscle Genes FNDC5 and PPARGC1A in a Rat Model of Alzheimer's Disease, Current Alzheimer Research, October 2022, Bentham Science Publishers, DOI: 10.2174/1567205020666221207103109.
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