What is it about?
The indiscriminate use of herbicides makes weeds resistant, increasing the demand for more efficient herbicides. Novel potential herbicides were prepared from sorbic acid, being 8 dienamides and 6 epoxides. Subsequently, phytotoxic activities of sorbic acid and 14 synthesized compounds were evaluated against sorghum, onion, cucumber, lettuce, and beggartick seeds. Furthermore, the protein target of the most active substance in plants was identified in silico. Among the tested compounds, (2E,4E)-N-(p-fluorophenyl)hexa-2,4-dienamide (2c), (2E,4E)-N-(o-naphthyl) hexa-2,4-dienamide (2d), (E)-N-methylphenyl-3-((2R,3R)-3-methyloxiran-2-yl)acrylamide (3b), (E)-N-bromophenyl-3-((2R,3R)-3-methyloxiran-2-yl)acrylamide (3e), and (E)-N-methoxyphenyl3-((2R,3R)-3-methyloxiran-2-yl)acrylamide (3f) showed pronounced inhibitory activities, both of shoots and roots, making them candidates for promising herbicides. All compounds altered seed development, and compounds 2c, 2d, 3b, 3e, and 3f presented equal or superior results to the commercial control herbicide S-metolachlor. Docking studies suggest that enzyme mitogenactivated protein kinase can be the target of those compounds.
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Why is it important?
New Herbicides from Sorbic Acid: Promising Candidates Identified for Weed Control
Perspectives
The overuse of herbicides leads to resistant weeds, driving the need for more effective solutions. We've explored new herbicides derived from sorbic acid, including 8 dienamides and 6 epoxides. Testing these compounds against various seeds revealed promising candidates for weed control, such as (2E,4E)-N-(p-fluorophenyl)hexa-2,4-dienamide and others. These compounds not only inhibited shoot and root growth but also altered seed development. Importantly, some compounds performed as well as or better than the commercial herbicide S-metolachlor.
Professor Elson Santiago Alvarenga
Universidade Federal de Vicosa
Read the Original
This page is a summary of: Study of the Interference in Target Seed Germination Caused by Dienamides and Epoxy Derivatives, in the Search for New Herbicides, Journal of the Brazilian Chemical Society, January 2023, Sociedade Brasileira de Quimica (SBQ),
DOI: 10.21577/0103-5053.20230113.
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