What is it about?

Both deficient estrogen exposure and decreased reactivity of estrogen receptors (estrogen resistance) with insufficient compensatory hyperestrogenism may increase the risk of TNBCs. In insulin resistant patients with obesity, metabolic syndrome or diabetes, a deficient ER signal in the background is the key to an increased TNBC risk.

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Why is it important?

Most unique and timely in this work is the explanation of complex associations between excessive and defective estrogen signaling (multiparity and nulliparity) and breast tumors with different ER expressions. The tumor suppressing effect of excessive and the liberating effect of defective estrogen supply has disproportional impact on ER+ and ER- cancers. The higher the ER expression of tumor cells, the stronger the genome repairing capacity of estrogen exposure.


The grade of defect in metabolic and hormonal equilibrium is directly associated with TNBC risk for both premenopausal and postmenopausal women.

professor Zsuzsanna Suba
National Institute of Oncology Budapest

Read the Original

This page is a summary of: Triple-negative breast cancer risk in women is defined by the defect of estrogen signaling: preventive and therapeutic implications, OncoTargets and Therapy, January 2014, Taylor & Francis,
DOI: 10.2147/ott.s52600.
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