Triple-negative breast cancer risk in women is defined by the defect of estrogen signaling: preventive and therapeutic implications

Zsuzsanna Suba
  • OncoTargets and Therapy, January 2014, Dove Medical Press
  • DOI: 10.2147/ott.s52600

Defective estrogen surveillance leads to TNBC risk

What is it about?

Both deficient estrogen exposure and decreased reactivity of estrogen receptors (estrogen resistance) with insufficient compensatory hyperestrogenism may increase the risk of TNBCs.

Why is it important?

Most unique and timely in this work is the explanation of complex associations between excessive and defective estrogen signaling (multiparity and nulliparity) and breast tumors with different ER expressions. The tumor suppressing effect of excessive and the liberating effect of defective estrogen supply has disproportional impact on ER+ and ER- cancers. The higher the ER expression of tumor cells, the stronger the killing capacyty of estrogen exposure.

Perspectives

professor Zsuzsanna Suba
National Institute of Oncology Budapest

The grade of defect in metabolic and hormonal equilibrium is directly associated with TNBC risk for both premenopausal and postmenopausal women.

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http://dx.doi.org/10.2147/ott.s52600

The following have contributed to this page: professor Zsuzsanna Suba