Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

Jan Keppel Hesselink, Hekker
  • Journal of Pain Research, October 2012, Taylor & Francis
  • DOI: 10.2147/jpr.s32143

Palmitoylethanolamide: a supplement effective in chronic pain

What is it about?

We explain the background of the nutraceutical palmitoylethanolamide, freely available as the supplement PeaPure, and describe the efficacy and safety in a number of treatment resistant pain patients. PeaPure has also been evaluated related to plasma levels of PEA and after intake PEA levels measured increased at least 2-4 fold.

Why is it important?

Palmitoylethanolamide is a natural compound, endogenous produced in our body, and since 1957 well known for its therapeutic properties. The compound has a demonstrated analgesic effect and can be easily combined with any other analgesic (painkiller).


jan keppel hesselink
Institute Neuropathic Pain

Meanwhile palmitoylethanolamide is recognized as an analgesic supplement, with an NNT of 1.5 in sciatic pain. This has been published in oktober 2015: Both clinical as well as preclinical data supports the fact that PEA cal also enhance analgesic effects of classical painkillers, and thus may lead to lower dosages of opiates, pregabalin, etc. This increases compliance and leads to more effect for the patients, with less side effects.

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