Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage

Mariele Charão, Caroline Souto, Natália Brucker, Anelise Barth, Denise Jornada, Daiandra Fagundes, Daiana S. de Ávila, Vera Eifler-Lima, Silvia Guterres, Adriana Pohlmann, Solange Garcia
  • International Journal of Nanomedicine, August 2015, Dove Medical Press
  • DOI: 10.2147/ijn.s84909

Polarimetry as an Analytical Method to Quantify Limonene-Loaded Nanoemulsions.

What is it about?

we reported the validation of a polarimetric method for the quantification of limonene-loaded nanoemulsions.

Why is it important?

Because Polarimetry is a rapid and reliable method to quantify chiral species in colloidal dispersed formulations, such as nanoemulsions.

Perspectives

Dr Vera Lucia Eifler-Lima
FACULDADE DE FARMÁCIA UFRGS

The use of polarimetry to measure the limonene in nanoemulsion represents an alternative analytical method, once the study demonstrated to be specific, linear, precise and accurate in the concentration range of 0.7 to 10 mg mL-1. Therefore, the method described here can be used in laboratories, once polarimetry is a low cost technique, easy to handle, reliable and fast, considering that evaporation steps are not required. Furthermore it allows the reduction of the volume of dangerous residues promoting benefits to the public health and to the environment.

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http://dx.doi.org/10.2147/ijn.s84909

The following have contributed to this page: Professor Solange Cristina Garcia, Dr Vera Lucia Eifler-Lima, Miss Silvia S Guterres, and Daiana Avila