What is it about?
The cytotoxicity assay, hemolysis test, micronucleus (MN) assay, and detection of acute toxicity in mice and beagle dogs were introduced to evaluate the biocompatibility of self-assembled Fe3O4@Au composite MNPs in this research.
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Why is it important?
The results of this study show that Fe3O4@Au composite MNPs appear to be highly biocompatible and safe nanoparticles according to the evaluation of toxicity in vivo and in vitro.
Perspectives
Considering that some of the Food and Drug Administration-approved MRI contrast agents are made of Fe3O4, Fe3O4@Au composite MNPs have a potential to be used as safe optical and thermal agents, allowing the combination of cancer detection and cancer-specific hyperthermic treatment. The results of this study provide experimental foundation for further clinical research and evaluation of this promising material.
Yuntao Li
Nanjing Medical University
Read the Original
This page is a summary of: Biocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo, International Journal of Nanomedicine, November 2011, Taylor & Francis,
DOI: 10.2147/ijn.s24596.
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