What is it about?
One of the ways to treat osteochondral defects is use for scaffolds. We developed a bilayer scaffold to mimic the cartilage and the underlying subchondral bone. Implantation of the acellular scaffold at defect site led to recruitment of host cells and differentiation to give rise to a functional complex tissue. The uniqueness of the work lies in the fact that a single, natural, biocompatible polymer was used as a scaffold to mimic a physiologically complex tissue at the knee.
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Why is it important?
The work would lead to a new material for further assessment in clinical settings
Perspectives
The similar publications report the use of 2 different materials that mimic the cartilage and the underlying subchondral bone. The fact that mechanical properties of bacterial cellulose can be tailored is unique. The articles is a result of my collaboration and I had always looked forward to this publication. It will be the foundation for studying many more aspects together.
Jyutika Rajwade
Agharkar Research Institute, Pune, Maharashtra, India
Read the Original
This page is a summary of: In vitro and in vivo studies of a novel bacterial cellulose-based acellular bilayer nanocomposite scaffold for the repair of osteochondral defects, International Journal of Nanomedicine, September 2017, Dove Medical Press,
DOI: 10.2147/ijn.s137361.
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