Diverse pathomechanisms leading to the breakdown of cellular estrogen surveillance and breast cancer development: new therapeutic strategies

Zsuzsanna Suba
  • Drug Design Development and Therapy, September 2014, Dove Medical Press
  • DOI: 10.2147/dddt.s70570

The stronger the estrogen resistance, the higher the promising dose of estrogen therapy.

What is it about?

When insulin resistance is the primary initiator of pathologic processes, reactive hyperinsulinism and estrogen deficiency are the characteristic laboratory findings. When estrogen resistance is the primary disorder, reactive hyperestrogenism is the predominant hormonal alteration. Estrogen deficiency and androgen excess without counteractions leads to further breakdown of cellular mechanisms, while estrogen excess is beneficial, since only its insufficient overproduction leads to progressive pathologies and malignancies.

Why is it important?

Since cellular estrogen surveillance has crucial role in mammary health, either the inhibition of aromatase enzyme activity or estrogen receptor blockage jeopardizes the structural and functional integrity of female breast.


professor Zsuzsanna Suba
National Institute of Oncology Budapest

The higher the resistance of estrogen receptors, the higher is the promising dose of estrogen for prevention and treatment of breast cancer.

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The following have contributed to this page: professor Zsuzsanna Suba