What is it about?
Sedation practices for colonoscopy indeed vary widely around the globe. Due to a lack of data on intravenous paracetamol, we aimed to investigate the clinical efficacy of intravenous paracetamol compared to intravenous fentanyl under propofol deep sedation for colonoscopy.
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Why is it important?
Because of its safety and fewer complications, iv paracetamol is considered an appropriate alternative for analgesia during colonoscopy. The authors suppose that paracetamol which lacking of respiratory depression, will be superior for the vulnerable patients especially the elderly, obese, and those with obstructive sleep apnea. Additional studies are needed to find out the cost-effectiveness and potential complications in these specific patient populations. These outcomes hold significant value for ambulatory surgery.
Perspectives
Propofol deep sedation combined with iv paracetamol was safe and effective to complete the colonoscopy. On contrary, the sedation-related complications including upper airway obstruction and hypoxia were significantly higher in the fentanyl group. Intravenous paracetamol was the alternative analgesic adjuvant for colonoscopy. However, further studies focusing on high-risk populations would be necessary to solidify iv paracetamol’s role in sedation practices.
Professor Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
Read the Original
This page is a summary of: Clinical Efficacy Between Intravenous Paracetamol and Intravenous Fentanyl for Propofol Deep Sedation in Colonoscopy: A Randomized Controlled Trial, Drug Design Development and Therapy, January 2025, Taylor & Francis,
DOI: 10.2147/dddt.s479084.
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