COPD,eosinophilia

What is it about?

COPD exacerbations requiring hospitalization increase morbidity and mortality. In this study we aimed to evaluate mortality and outcomes of eosinophilic and non-eosinophilic COPD exacerbations and identify new biomarkers that predict survival. In our study it was determined that non-eosinophilic patients with COPD exacerbations with high CRP and NLR values had worse outcomes than eosinophilic patients. Peripheral blood eosinophil and neutrophil lymphocyte ratio can be helpful markers to guide treatment decisions.

Featured Image

Why is it important?

The inflammatory markers CRP and NLR are more likely to be elevated in non-eosinophilic COPD exacerbations. NLR levels can be more easily obtained than CRP in clinical practice, and it is a cheaper, quicker test. These findings support the theory that Peripheral blood eosionophil with low CRP and NLR values are associated with noninfectious COPD attacks and they are useful biomarkers for guiding management of COPD exacerbations including steroid treatment.