What is it about?
The study examined 1,958 histopathology reports and documented nerve sprouting associated with scar tissue in areas of fatty degeneration of the jawbone. The authors propose that this nerve sprouting could increase local norepinephrine release and potentially contribute to palpitations or heart rhythm disturbances. The study documents the tissue changes, while the proposed link to cardiac symptoms remains a hypothesis.
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Photo by Anna Maslenkina on Unsplash
Why is it important?
The study shows that some jawbone cavitations contain nerve fibers that have sprouted near scar tissue. This finding gives researchers a concrete starting point for testing whether these local nerve changes are associated with palpitations or heart rhythm disturbances. Establishing that link would require studies that pair tissue findings with objective cardiac monitoring.
Perspectives
Future studies should test whether nerve sprouting in jawbone cavitations is associated with objectively documented heart rhythm disturbances. Prospective studies could pair tissue analysis with ambulatory ECG monitoring and examine whether the sprouting fibers are sympathetic and whether they increase local norepinephrine release.
Dr Johann Eugen Lechner
Clinic Complementary Dentistry Munich
Read the Original
This page is a summary of: Peripheral Nerve Alterations in Jawbone Cavitations: Histopathological Findings from a Retrospective Observational Study, Clinical Cosmetic and Investigational Dentistry, November 2026, Taylor & Francis,
DOI: 10.2147/ccide.s622295.
You can read the full text:
Resources
Lechner J, Vasconcelos e Cruz J, Seifer T, Notter F, Schick F. Peripheral Nerve Alterations in Jawbone Cavitations: Histopathological Findings from a Retrospective Observational Study. Clin Cosmet Investig Dent. 2026;18:622295
We published a new article about FDOJ, Axon Sprouting, and Cardiac Arrhythmias—A new Neurovegetative Discovery for Dentists: Lechner J, Vasconcelos e Cruz J, Seifer T, Notter F, Schick F. Peripheral Nerve Alterations in Jawbone Cavitations: Histopathological Findings from a Retrospective Observational Study. Clin Cosmet Investig Dent. 2026;18:622295 https://doi.org/10.2147/CCIDE.S622295 This newly published study documents scar-associated nerve sprouting based on an analysis of 1,958 histological findings and broadens the perspective on fatty-degenerative changes in the jawbone (FDOK): The focus is on a possible chain of events: RANTES/CCL5 inflammatory signals promote sympathetic axon sprouting and increased norepinephrine release. The resulting increase in sympathetic activity may contribute to tachycardia and cardiac arrhythmias. The reported improvements in cardiac symptoms and cardiac arrhythmias following surgical treatment of FDOK are clinically noteworthy. As a practical implication for dental practice, FDOK areas warrant increased targeted diagnostic attention in cases of unexplained cardiovascular symptoms—even when X-ray findings are unremarkable. CaviTAU® serves here as a radiation-free complementary examination, providing targeted insights into medullary structural defects. The medical benefit for both the patient and the dentist lies in expanding the diagnostic basis for cardiovascular symptoms, as CaviTAU® identifies the localization of axon sprouting and norepinephrine as a possible cardiac cause. Thus, sonography complements structural imaging by providing an additional integrative medical approach to the medullary tissue environment.
Lechner J, Vasconcelos e Cruz J, Seifer T, Notter F, Schick F. Peripheral Nerve Alterations in Jawbone Cavitations: Histopathological Findings from a Retrospective Observational Study. Clin Cosmet Investig Dent. 2026;18:622295
We published a new article about FDOJ, Axon Sprouting, and Cardiac Arrhythmias—A new Neurovegetative Discovery for Dentists: Lechner J, Vasconcelos e Cruz J, Seifer T, Notter F, Schick F. Peripheral Nerve Alterations in Jawbone Cavitations: Histopathological Findings from a Retrospective Observational Study. Clin Cosmet Investig Dent. 2026;18:622295 https://doi.org/10.2147/CCIDE.S622295 This newly published study documents scar-associated nerve sprouting based on an analysis of 1,958 histological findings and broadens the perspective on fatty-degenerative changes in the jawbone (FDOK): The focus is on a possible chain of events: RANTES/CCL5 inflammatory signals promote sympathetic axon sprouting and increased norepinephrine release. The resulting increase in sympathetic activity may contribute to tachycardia and cardiac arrhythmias. The reported improvements in cardiac symptoms and cardiac arrhythmias following surgical treatment of FDOK are clinically noteworthy. As a practical implication for dental practice, FDOK areas warrant increased targeted diagnostic attention in cases of unexplained cardiovascular symptoms—even when X-ray findings are unremarkable. CaviTAU® serves here as a radiation-free complementary examination, providing targeted insights into medullary structural defects. The medical benefit for both the patient and the dentist lies in expanding the diagnostic basis for cardiovascular symptoms, as CaviTAU® identifies the localization of axon sprouting and norepinephrine as a possible cardiac cause. Thus, sonography complements structural imaging by providing an additional integrative medical approach to the medullary tissue environment.
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