What is it about?
Perturbations in cellular metabolism have been linked to the development of cancer. Malic enzyme 1 (ME1), a cytosolic protein, is NADP-dependent and responsible for NADPH generation. It is widely expressed in the human body and its sequence is highly conserved among species, indicating that it is responsible for important biological functions. The function of ME1 in gastric carcinogenesis should be investigated.
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Why is it important?
Our results provide evidence that ME1 is a key factor for gastric cancer. ME1 might be pro-oncogenic during both the development and migration of gastric cancer; it also might be related to gastric cancer patient survival.
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This page is a summary of: Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients, OncoTargets and Therapy, July 2019, Dove Medical Press, DOI: 10.2147/ott.s203228.
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