What is it about?

Recurrent gene fusions involving several kinases have been described in an emerging group of spindle cell tumors with ambiguous phenotype; however, ALK rearrangements have not been reported to date. Herein, we report a novel PPP1CB-ALK fusion in one such case.

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Why is it important?

In this report, we provide additional genetic insight into this new tumor type highlighting the importance of using multiple methodologies of molecular testing to improve diagnostic sensitivity.


There is growing evidence of morphologically different soft tissue neoplasms harboring kinase-related fusions while targeted therapies are progressively emerging as an alternative option. Are we moving towards a paradigm shift where all these entities will be lumped under the designation of "kinase-driven neoplasms"? Time will tell - sooner than later...

Oscar Lopez-Nunez
Cincinnati Children's Hospital Medical Center

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This page is a summary of: Novel PPP1CB-ALK fusion in spindle cell tumor defined by S100 and CD34 coexpression and distinctive stromal and perivascular hyalinization, Genes Chromosomes and Cancer, April 2020, Wiley, DOI: 10.1002/gcc.22844.
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