What is it about?

In this original paper, we investigate the disparity of state of glucose metabolism between normal type 2 diabetic (T2D) patients and T2D with psoriasis which mostly is caused by the autoimmune process and lead to inflammation in the skin. We hypothesis this is a critical contributor to the patients with Psoriasis in T2D, who may manifest with higher insulin resistance. In this paper, we also compared other metabolic factors between the two groups.

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Why is it important?

Psoriasis is characterized by the different extent of subcutaneous inflammation caused by autoimmune, as skin is the largest organ in the human body, it can be assumed that skin is also an insulin target organ. Based on these assumptions, we could explain the findings why T2D patients with Psoriasis may manifest with higher insulin resistance. In accord with this finding, there also emerged massive reports on the influence of psoriasis on the metabolic syndrome and cardiovascular diseases. Therefore, this is an important notion, for the treatment of T2D like insulin sensitizer TZD could relieve the symptoms of Psoriasis in these patients, and the improvement in Psoriasis by some anti-immune therapy could ameliorate the glycemic in T2D.


More and more investigations have revealed the intimate relationship between psoriasis and T2D. We could expect more advancement to reveal the metabolic relationships between these two disorders and contribute to benefits in complications of these two diseases.

Dr. Song Wen
Shanghai Pudong Hospital

Read the Original

This page is a summary of: Psoriasis Exacerbates the State of Insulin Resistance in Patients with Type 2 Diabetes, Diabetes Metabolic Syndrome and Obesity, May 2021, Taylor & Francis,
DOI: 10.2147/dmso.s312420.
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