What is it about?

This study delved into the heterogeneity of endothelial cells by analyzing single-cell sequencing data from different studies. Among the findings were seven different endothelial subpopulations that have different characteristics and functions. In conclusion,we created a detailed map of normal human kidney endothelial cells, which can help us understand how these cells change in different situations like diseases and aging. They made this data available online for other scientists to explore.

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Why is it important?

The heterogeneity of kidney endothelial cells, which are important component cells supporting kidney function, has not been systematically analyzed. This study integrated single-cell transcriptome sequencing data from normal human kidney samples to determine the identity and the functional differences in endothelial cell subpopulations in the human kidney. This study also revealed similarities and differences in the renal endothelial cell population between mice and humans. These findings can serve as a reference for the comprehensive characterization of endothelial cells in healthy and diseased kidneys.

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This page is a summary of: Integrated Single-Cell Transcriptomic Atlas of Human Kidney Endothelial Cells, Journal of the American Society of Nephrology, February 2024, Wolters Kluwer Health,
DOI: 10.1681/asn.0000000000000320.
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