Candesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats

What is it about?

Losartan and candesartan improved hepatic fibrosis in rats possibly through angiotensin-II receptor blocking, antioxidant, and anti-inflammatory activities. Only candesartan improved motor dysfunction possibly due to better brain penetration and slower “off-rate” from the receptors.

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