What is it about?
Necrotizing enterocolitis results from an initial aggression to the intestinal mucosa due to the action of several factors, including genetic ones, on an immature gastrointestinal system. Inappropriate activation of the NFKB1 gene by genetic polymorphisms has been associated with many processes in inflammatory bowel diseases, especially in necrotizing enterocolitis. The absence of the -94ins/delATTG polymorphism in the NFKB1 gene in newborns with and without necrotizing enterocolitis does not rule out the possibility of the existence of other genetic alterations in this or in other genes related to the pathophysiology of this condition.
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Perspectives
Greater knowledge of this molecular relationship is important not only for understanding the physiology and physiopathogenesis of necrotizing enterocolitis but also for discovering its genetic causes. This will provide new perspectives and guide humanized and personalized protocols, through therapeutic schemes and different technologies, which provide early diagnosis and interventions, even in the face of these genetic alterations, in addition to stimulating the continuity of scientific research.
PROF DR VANIA PIATTO
FAMERP
Read the Original
This page is a summary of: IS -94INS/DELATTG POLYMORPHISM IN THE NUCLEAR FACTOR KAPPA-B1 GENE (NFKB1) ASSOCIATED WITH NECROTIZING ENTEROCOLITIS?, ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), January 2022, FapUNIFESP (SciELO),
DOI: 10.1590/0102-672020220002e1717.
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