What is it about?
The electroencephalogramm (EEG) is the only test to diagnose absence epilepsy and it also provides essential information about the nature of functional bran activity. Absence seizures are produced by thalamo-cortical network that normally produces sleep spindles. Therefore, sleep spindles and absence seizures are functionally related phenomena. This review describes distinctive EEG feature of sleep spindles in a genetic rat model of absence epilepsy (WAG/Rij).
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Why is it important?
Absence epilepsy is a particular epileptic syndrome in which patients have only few and mild clinical correlates. Knowing specific EEG changes of sleep spindles that associate with absence epilepsy is helpful for early diagnosis of absence seizures.
Perspectives
It is interesting to establish what changes in EEG sleep spindles are associating with high risk for developing absence epilepsy and what are associating with undeveloped absence seizures. This is particularly related to children with family/genetic history of absence epilepsy.
Dr Evgenia Sitnikova
Institute of Higher Nervous Activity and Neurophysiology RAS
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This page is a summary of: Sleep spindles in rats with absence epilepsy, Sleep Spindles & Cortical Up States, November 2017, Akademiai Kiado,
DOI: 10.1556/2053.01.2017.004.
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