What is it about?
This study reveals detailed entry mechanism of tick-borne zoonotic viruses, Heartland bandavirus and Dabie bandavirus where host membrane glycosphingolipid is critical for viral glycoprotein Gc-mediated membrane fusion.
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Why is it important?
Due to climate changes, there has been a large expansion of emerging tick-borne zoonotic viruses. Our study provides a potential therapeutic target to prevent emerging tickborne virus infection.
Read the Original
This page is a summary of: Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion, PLoS Pathogens, March 2023, PLOS,
DOI: 10.1371/journal.ppat.1011232.
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