What is it about?
Glucose is a critical nutrient for macrophages, and they use it as an energy source to carry out their functions. When macrophages encounter Salmonella, the bacteria trigger a series of changes in the macrophages' metabolism that result in a reduction in glucose uptake and utilization. This reduction in glucose metabolism leads to a decrease in the macrophages' ability to engulf and destroy the bacteria.
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Why is it important?
Understanding how Salmonella evades the immune response by manipulating macrophage glucose metabolism is important because it can help identify new targets for developing treatments to combat infectious diseases caused by microbes such as Salmonella. Additionally, this research can also contribute to a better understanding of the molecular mechanisms behind bacterial evasion of the immune system, which may have implications for the development of treatments for other bacterial infections as well.
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This page is a summary of: Salmonella Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense, PLoS Pathogens, September 2021, PLOS, DOI: 10.1371/journal.ppat.1009943.
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