What is it about?
Evogliptin, an anti-diabetic drug had positive impact on various cardiovascular events including inflammation and vascular calcification, an active process driven by vascular smooth muscle cell phenotypic transition means osteogenesis (like bone formation). Sphingolipids such as Ceramide mediates inflammation and calcification in the vascular tissue. We investigated whether Evogliptin ameliorate vascular calcification besides its antidiabetic effect, and role of sphingolipids under these diseased conditions.
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Why is it important?
Firstly, the present findings indicate that Sphingolipid-Ceramide enhanced the mineralization, calcification and pyroptosis, means programmed inflammatory cell death in high phosphate‐induced vascular smooth muscle cells. Blocking the inflammation particularly inflammasomes prevented pyroptotic cell death and osteogenesis of vascular smooth muscle cells. Furthermore, we found that Evogliptin alleviates vascular calcification by ameliorating enzyme Sphingomyelinase (SMase) (which hydrolyse Sphingomyelin to Ceramide in de-novo synthesis) involved in sphingolipid pathway, blocking osteogenesis and associated inflammatory cell death via modulation of inflammatory/inflammasome pathway.
Perspectives
Our findings are consistent with the literature which recently reported the beneficial and pleiotropic effects of Evogliptin on cardiovascular disorders, and added to insights that encourage the use of Evogliptin to prevent the development of calcification and inflammatory cell death in vascular smooth muscle cells which contributes to the underlying pathology of cardiovascular diseases.
Owais Bhat
Read the Original
This page is a summary of: Evogliptin prevents ceramide-induced pyroptosis during calcification via modulation of NLRP3/GSDM-D mediated pathway in Vascular Smooth Muscle Cells, PLOS One, December 2025, PLOS,
DOI: 10.1371/journal.pone.0337200.
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