What is it about?
TTLL12 is a promising target for therapeutic intervention since it has been implicated in tumour progression and the innate immune response to viral infection. We identified a novel property of TTLL12, suppression of the cell toxicity of nitrotyrosine, which is produced by oxidative stress, modifies the cytoskeleton and is involved in cancer progression. We developed a robust assay based on this activity and used it to screen a collection of low-molecular weight molecules. Two molecules were identified that inhibit the pro-oncogenic activity of TTLL12.
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Why is it important?
The molecules from the screen will be useful for the development of drugs to treat cancer and other pathologies that involve TTLL12.
Perspectives
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This page is a summary of: TTLL12 has a potential oncogenic activity, suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated α-tubulin, that can be overcome by molecules identified by screening a compound library, PLoS ONE, February 2024, PLOS,
DOI: 10.1371/journal.pone.0296960.
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