What is it about?
Schwannomas are a neurological tumors that are caused by the loss of a specific protein called Merlin. We have shown that Merlin is activated in response to a phopspholipid based signaling molecule, PIP2, by forming a dimer. This observation gives us critical insight into how Merlin functions and why it's loss causes Schwannomas.
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Why is it important?
Knowing the mechanism by which Merlin performs its normal function will help us understand the changes that cause Schwannomas when it is lost. This, in turn, will give us a better chance to devise more effective treatments for this disease.
Perspectives
I am proud of this work, represents fills in the blanks about how Merlin works that will greatly help our future work devoted to understanding this disease.
Robert Hennigan Robert Hennigan
Cincinnati Children's Hospital Medical Center
Read the Original
This page is a summary of: Merlin tumor suppressor function is regulated by PIP2-mediated dimerization, PLOS One, February 2023, PLOS,
DOI: 10.1371/journal.pone.0281876.
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