What is it about?

Cyclic vomiting syndrome (CVS) is a gastrointestinal disorder that is characterized by recurrent episodes of vomiting. Our study provides the first large-population-based estimates of CVS prevalence and incidence in Japan, and currently, the only estimates for adult CVS in Japan.

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Why is it important?

A total of 2,093 patients with CVS were identified from 3,506,144 individuals. The overall age-and-sex-standardized prevalence was 0.32 per 1,000 population (95% confidence interval [CI]: 0.30–0.34), projected to approximately 49,000 patients with CVS across Japan. The pediatric age-and-sex-standardized prevalence was 2.10 per 1,000 population (95% CI: 2.01–2.19), and the adult prevalence was 0.05 per 1,000 population (95% CI: 0.04–0.06). Marked sex differences were observed before and after 12 years of age.


Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. The study findings contribute to the knowledge related to patient characteristics and management as well as the low diagnosis of CVS, especially among adults, in Japan, and may shed light on CVS that have been largely dismissed or unrecognized among Asian adults.

Motonobu Sakaguchi

Read the Original

This page is a summary of: Prevalence and incidence of cyclic vomiting syndrome in Japan: A study using Japanese claims data, PLoS ONE, December 2022, PLOS, DOI: 10.1371/journal.pone.0279502.
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