What is it about?
This study conducted in mice examined how alcohol affected the conversion of dimethyl fumarate to its active metabolite. Dimethyl fumarate is a drug used in the treatment of multiple sclerosis. Alcohol inhibited the conversion of dimethyl fumarate to its active metabolite and reduced the amount of the active metabolite in the brain.
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Why is it important?
This study shows that consuming alcohol along with dimethyl fumarate may reduce the effectiveness of this medication in the treatment of multiple sclerosis.
Perspectives
I hope this article will promote a greater understanding of the potential for alcohol to interact with dimethyl fumarate and other drugs metabolized by the same enzyme, such as oseltamivir, tenofovir alafenamide remdesivir, and sofosbuvir.
Casey Laizure
University of Tennessee
Read the Original
This page is a summary of: Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis, PLOS One, November 2022, PLOS,
DOI: 10.1371/journal.pone.0278111.
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