What is it about?
This article illustrates, yet again, how often cluster randomized trials (cRCTs) are mistakenly designed, analyzed, and interpreted.
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Why is it important?
This represents a serious challenge to many areas, especially childhood obesity and nutrition research, because it leads to distortion in the scientific record as to the evidence regarding the effects of interventions (prevention; treatment; experimental tests).
Perspectives
Editors, authors, and funders all have a responsibility to do better in promoting rigor, preventing errors, and post-publication error detection and correction.
David Allison
Indiana University Bloomington
Read the Original
This page is a summary of: Accounting for the clustering and nesting effects verifies most conclusions. Corrected analysis of: “Randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometa..., PLOS One, October 2022, PLOS,
DOI: 10.1371/journal.pone.0275242.
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