What is it about?
The paper is about the pathogenesis of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD).
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Why is it important?
The paper provides a unifying explanation for two cardinal features of SHPT: (1) a high parathyroid hormone concentration ([PTH]) is required to maintain a normal plasma calcium concentration; (2) [PTH] rises and falls with dietary phosphate intake.
Perspectives
Animal experiments done decades ago showed that [PTH] can be kept normal in CKD if phosphate intake is reduced in proportion to the reduction in glomerular filtration rate. Our paper provides an explanation for that observation.
Kenneth Phelps
Albany Veterans Affairs Medical Center
Read the Original
This page is a summary of: Chemical evidence for the tradeoff-in-the-nephron hypothesis to explain secondary hyperparathyroidism, PLOS One, August 2022, PLOS,
DOI: 10.1371/journal.pone.0272380.
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