What is it about?
We demonstrated the anticancer activity of FDNVs against two colorectal cancer cell lines, HT-29 and HCT116. Interestingly, FDNVs were not toxic to a normal colon epithelial cell line, CCD 841 CoN. FDNVs exhibited selective uptake by the colorectal cancer cell lines but not the normal colon epithelial cell line. Moreover, dose- and time-dependent FDNV-induced apoptosis was only observed in the colorectal cancer cell lines.
Featured Image
Why is it important?
In the present study, we provided the first isolation and characterization of nanovesicles from fingerroot. More importantly, we demonstrated promising selective anticancer effects of these nanovesicles against CRC cells
Perspectives
This study demonstrated the anticancer effect of FDNVs against CRC cells with low toxicity to normal colon epithelial cells, indicating its selective anticancer property. Furthermore, the anticancer effect of FDNVs was mediated through disruption of intracellular redox homeostasis and induction of apoptosis pathway. Thus, FDNVs may be a promising intervention for CRC patients.
Dr Saharut Wongkaewkhiaw
Khon Kaen University
Read the Original
This page is a summary of: Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.), PLOS One, April 2022, PLOS,
DOI: 10.1371/journal.pone.0266044.
You can read the full text:
Contributors
The following have contributed to this page
