What is it about?

This publication is about the prevalence of invasive infections, risk factors, and mortality risk in CRE-colonized patients and how active carbapenem-resistant Enterobacterales (CRE) surveillance minimizes the spread of CREs in high-risk settings such as ICUs. t is about a retrospective cohort study analyzing 1,920 patients identified using an active CRE surveillance protocol, admitted to an adult intensive care unit in southeastern Brazil

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Why is it important?

CRE-colonized patients demonstrated an increased chance of invasive infection, mainly for Klebsiella pneumonia. In addition, the mortality risk was significantly higher among colonized and colonized-infected and previous aminopenicillins exposure. It is known that hospitalization time and costs increase in infected patients.


"We need to be aware of the spread of bacteria resistant to antibiotics both in the community and in hospital environments. Therefore, health policies that intervene in the early detection of CRE colonization, through screening testing, and the effective implementation of preventive measures together with health teams are important tools in containing this spread of CRE."

Mabel Gomides

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This page is a summary of: The importance of active surveillance of carbapenem-resistant Enterobacterales (CRE) in colonization rates in critically ill patients, PLoS ONE, January 2022, PLOS,
DOI: 10.1371/journal.pone.0262554.
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