What is it about?
The human taste sensory system evolved to respond to sugars, as well as other macro- and micro-nutrients in addition to toxins. We provide evidence that the sugar taste system in humans includes both the T1R2-T1R3 taste receptors, as well as the sodium-glucose co-transporter (SGLT), which is a component of the glucose metabolic signaling pathway. This observation indicates that the human sugar taste system has signaling components that parallel those of the pancreatic beta islet cells that release insulin into blood when plasma-glucose increases.
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Why is it important?
It is unclear why sugar detection cells around the body have the dual detection mechanisms of T1R taste receptors and metabolic signaling pathway components. But these two sugar signaling systems are likely complementary and serve somewhat different roles. At present, we do not know their respective roles for human taste, but in rodent experiments, the metabolic signaling pathway in taste tissue causes pre-absorptive insulin to be released in anticipation of ingested and absorbed carbohydrates. Metabolic pathway signaling might also participate in food reward and influence liking and/or wanting of foods both while ingesting and when seeking meals in the future.
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This page is a summary of: Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway, PLoS ONE, October 2021, PLOS, DOI: 10.1371/journal.pone.0256989.
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