What is it about?
It was found that prednisolone successfully alleviated inflammation and interstitial renal fibrosis and then inhibited glycolysis, which consequently led to reduce methylglyoxal, GLO1, and D-lactate, as well as other glycolysis-related proteins.
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Why is it important?
Our findings support that inhibition of glycolysis might be one of the mechanisms in prednisolone treatment for aristolochic acid nephropathy. These glycolysis parameters (methylglyoxal, GLO1, and D-lactate) increased in the chronic aristolochic acid nephropathy, which were quite different from acute kidney injury model.
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This page is a summary of: Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry, PLOS One, January 2020, PLOS,
DOI: 10.1371/journal.pone.0227838.
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