What is it about?
Type 2 diabetic retinopathy is the main cause of acquired blindness in adults. The aim of this work was to examine the retinal function of the sand rat Psammomys obesus as an animal model of diet-induced type 2 diabetes when subjected to a hypercaloric regimen.
Featured Image
Why is it important?
The present study clearly demonstrated for the first time that long-lasting and significant alterations in visual function detected by full-field ERG take place after 28 weeks of diet-induced type 2 diabetes in the retina of the sand rat. Thus, the diabetic sand rat appears to be an animal model that mimics several important features of the human form of diabetic retinopathy. The results confirm the validity of the P.obesus as a useful translational model to study diet-induced type 2 diabetic retinopathy (induced, like in humans, with the increase intake of high caloric food).
Perspectives
Adding this new model to the researchers’ armamentarium will not only be instrumental in increasing our understanding of the pathophysiology of human diabetic retinopathy but also help in the development of new therapeutic strategies.
Dr Ahmed Dellaa
ISBST
Read the Original
This page is a summary of: Electroretinographic evidence suggesting that the type 2 diabetic retinopathy of the sand rat Psammomys obesus is comparable to that of humans, PLoS ONE, February 2018, PLOS,
DOI: 10.1371/journal.pone.0192400.
You can read the full text:
Resources
Contributors
The following have contributed to this page
